Pharmacogenetics Test Solutions

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What is Pharmacogenetics?

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Pharmacogenetics refers to genetic differences in metabolic pathways which can affect an individual’s response to drugs in terms of therapeutic effect as well as adverse effects.

Taking a medication can often feel like a one-size-fits-all solution, yet it is estimated about 50% of patients do not respond effectively to the first medication prescribed by their physician.* This can cause delays in providing relief for patients, and can add additional cost to the healthcare system and a patient’s medical expenses.

KONE MOLECULAR LABS™ pharmacogenetic testing, also known as DNA drug-response testing, can help determine the most effective medicine for a person’s needs and sometimes assist in dosing guidelines for a wide array of medications. It helps physicians identify potential gene-drug interactions and drug-gene-drug interactions. KONE MOLECULAR LABS™ also reviews drug-drug interactions to help give a complete picture of a person’s medication therapy. Physicians will fill out a Drug Sensitivity Form (included with the pharmacogenomics DNA testing kit) and include a list of medications that their patient is currently taking or medications that the prescriber may want to consider for future use. KONE MOLECULAR LABS™ also has the capability to pull all the patient’s medications that they have had filled at a pharmacy through their health insurance over the past 180 days through a third-party vendor (SureScripts).

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Having a list of medications and a list of potential drug-drug interactions, gene-drug interactions, and drug-gene-drug interactions, along with this new genetic information, gives a prescriber a better understanding of why their patient may respond to a medication in a particular way. In other words: A more effective medication the first time around, eliminating the time, energy, and money wasted trying to find the “right” medication for a patient.

KONE MOLECULAR LABS™ is a pharmacogenetic lab and tests 30 genes to help identify mutations that may affect a person’s metabolism and/or response to medications. Once the pharmacogenetic analysis, conducted via a simple cheek swab sample, is complete, a Personalized Medication Report is reviewed by a pharmacist at KONE MOLECULAR LABS™ and prepared for the prescriber so that they can identify potential gene-drug interactions, drug-drug interactions, as well as drug-gene-drug interactions. KONE MOLECULAR LABS™ reports provide a pharmacogenomic analysis along with a Personalized Medication Guide, that list medications by specialty in categories of: Use as Directed, Use with Caution, or Recommend Alternative Medication. This list can be used for helping a prescriber choose new or alternative medications for their patient. The report is a powerful tool to help healthcare providers and their patients determine the best course of treatment.

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